Q1. Pyridoxine deficiency is caused due to which of the following
drugs?
rifampin
ethionamide
isoniazid
para-aminosalicyclic
acid
Answer- 3
Isoniazid usage especially in
alcoholics, diabetes, malnutrition and uremia can lead to pyridoxine deficiency
and hence its symptoms such as neuropathy.
Q2. Which of the following
drugs inhibit DNA dependant RNA polymerase ?
isoniazid
pyrizinamide
ethambutol
rifampin
Answer- 4
Q3. Rahul AIDS and
has acquired mycobacterium avium complex(MAC). Which of the following
medication shouldn’t be dispensed to him along with reverse transcriptase
inhibitor?
1.isoniazid
2.rifampin
3.ethionamide
4.ciprofloxacin
Answer-2
MAC is an opportunistic infection
occurring mostly in immunocompromised patients such as HIV. Rifampin decreases
activity of most reverse transcriptase inhibitors. It also causes contraceptive
failure
Q4. Which of the following metabolite of isoniazid causes
hepatotoxicity?
1.n-
acetyl isoniazid
2.isonicotinic
acid
3.acetyl
hydrazine
4.diacetyl
hydrazine
Answer-3
Q5. Discolouration of skin, sclera, tears etc can occur on prolonged
use of which anti mycobacterial drug?
1.rifampin
2.clofazimine
3.capreomycin
4.dapsone
Answer- both 1and 2. Both
the drugs are dyes
Q6. The action of which of the following
anti mycobacterial drug is dependant on acidic pH?
1.pyrizinamide
2.isoniazid
3.dapsone
4.clofazimine
Answer- 1. Pyrazinamide diffuses into M. tuberculosis, where the
enzyme pyrazinamidase converts pyrazinamide to
the active form pyrazinoic acid. Under acidic conditions, the
pyrazinoic acid that slowly leaks out converts to the protonated conjugate
acid, which is thought to diffuse easily back into the bacilli and accumulate.
The net effect is that more pyrazinoic acid accumulates inside the bacillus at
acid pH than at neutral pH
Q1. Why does only female
anopheles mosquito cause malaria?
A.because female
are evolutionarily designed to be cruel
B.because female
need blood from vertebral host to nourish eggs
C.males find it
difficult to suck blood
D.blood is the only
diet for female mosquitoes
Answer-
B
Q2. A patient is given an anti-malarial for
plasmodium falciparum. After taking the drug, he has anemia, cynosis,
tachypnoea and passage of dark urine. The patient is given which drug?
A.chloroquine
B.mefloquine
C.artesunate
D.primaquine
Answer-
D
Primaquine
is a 8-aminoquinine given to prevent relapse by action against hypnozoites. It
should not be given to Glucose-6-phosphate dehydrogenase deficient people. Glucose-6- phosphate dehydrogenase deficiency
leads to less production of NADPH via HMP pathway which is essential for RBC.
Lack of it leads to
heamolysis(passage
of dark urine), cynosis (lack of oxygen due less RBC) and anemia.
Q3. Which of the following 4-
amino quinoline is used for malaria as well as in rheumatoid arthritis and it
causes reversible retinal damage?
A.chloroquine
B.pyrimethamine
C.mefoquine
D.amodiaquine
Answer- A
Chloroquine causes retinal
damage due to its high plasma binding.
Q4. Which of the following can be used in
pregnancy to treat malaria?
A.quinine
B.primaquine
C.chloroquine
D.pyrimethamine
Answer-
C
Q5. Biguanides prevent
A.DHFRase
B.G6P dehydrogenase
C.Hemazoin
formation
D.None of the above
Answer-
Biguanides such as proguanil and pyrimethamine prevent DHFRase
Q6. A person suffers from
cancer and is undergoing chemotherapy. He now contracts malaria. Methotrexate
is given for the chemotherapy and pyrimethamine for malaria. This treatment
should be supplemented with?
A.Corticosteroids
B.Folinic acid
C.Dextrose solution
D.None of the above
Answer-B
Both
drugs are DHFRase inhibitors which inhibit formation of folic acid in the body.
Hence folinic acid is gven which is converted to active form of folic acid –
THF (tetra hydro folate) Q7. How do antibacterial drugs like doxycycline and sulphadoxine work against protozoal plasmodium parasite? A. mechanism unknown B. by affecting apicoplast enzymes C. by peroxide formation D. none of these Answer- B apicoplast is plasmid like organelle in plasmodium thought to be aquired from other organism by process of endosymbiosis during its course of evolution. This is used as a potential target against plasmodium.
Q1.Mr Tanay is showing internal bleeding due to
administration of warfarin, which other condition or conditions he suffers from
that lead to this?
A.Obstructive jaundice
B.Undergoing treatment with broad spectrum
antibiotics
C.Hypothyroidism
D.Both a and b
Answer- warfarin is a vitamin k analogue, If the absorption of vitamin k is hampered then the action of vitamin k analogue that is warfarin will be increased, as most warfarin will get bound due to lack of vitamin k at binding site. vitamin k is a fat soluble vitamin, thus in obstructive jaundice its absorption will be hampered thanks to no bile for its emulsification. similarly most broad spectrum antibiotics kill useful bacteria too that help in vitamin k absorption. warfarin action is increased in case of hyperthyroidism not hypothyroidism thus answer is D
Q2. Mrs. Neha is pregnant (3rd trimester)
she is also needs anticoagulants for prevention of myocardial infarction. Which
of the following should be prescribed?
A.Aspirin
B.Low molecular weight heparin
C.Warfarin
D.dicumerol
Answer- aspirin causes blockage of ductus arteriosus of fetus , warfarin and dicumerol is teratogenic, but Low molecular weight heparin can be used as its not polar and cant harm fetus thus answer is B
Q3. The activated prothrombin
time of Mr suresh was found to be elevated greatly. Which of the following lead
to this?
A.warfarin overdose
B.heparin overdose
C.heamophilia A nad B
D.both b and c could lead to the problem
Answer- prothrombin time is a measure of extrinsic pathway of coagulation. elevated prothrombin time indicates warfarin overdose.answer A
Q4. During performing the prothrimbin time (Pt)
and partial thromboplastin time(PTT) of Mr Ajay the laboratory guy forgot to
add citrate (or any other chelating agent). What could be the change in result
obtained?
A.Decreased Pt and ptt
B.Increased Pt and ptt
C.Increased pt but decreased ptt
D.Doesn’t matter
Answer- cheleating agents form complex with calcium preventing coagulation to obtain accurate coagulation time. if chelating agent not added then ptt and pt will be reduced. answer A
Q5. Kalpesh is heartbroken because he failed in his exams. In
the washroom he was found coughing up blood. His friends took him immediately
to the doctor. They also found rat poison bottle beside him which was empty. What
possibly should the doctor do ?
A.Administer protamine sulphate
B.Administer vit K in excess
C.Administer activated plasma
D.Administer aminocaproic acid
Answer- rat poison contains warfarin hence vitamin k can be given. protamine sulphate is used in case of warfarin overdose. aminocaproic acid is used in streptokinase overdose. but activated plasma should be given as vitmin k action is slow hence Ans C
Q1. To prevent drug toxicity after overdose what is used?
A. Syrup of ipecac C.
silica
B. Activated charcoal D.
both a and b
Q.2 Drug A is more lipid soluble and acidic than drug B which of the
following is TRUE for their absorption into the glomerular filtrate?
A. Greater absorption of drug A
than drug B C.
both are absorbed equally
B. lesser absorption of drug A
than drug B D.
none of these
Q3. The action of antagonist is
A. Opposite to that of agonist C.
No action
B. Similar to action of agonist D.
same as inverse agonist
Q4. Functional antagonist is
A. Act on same receptor C.
both a and b
B. Act on different receptors D.
there is nothing called functional
Antagonist
Q5.Binding site for G protein coupled receptors is
A. outer side of membrane C.
In between alpha helix
B. inner side of membrane D.
both a and c
Q6. Sildenafil (Viagra)
A. phosphodiesterase inhibitor C.
cause vasoconstriction
B. prolongs action of c GMP D.
both a and b
Q7.Nicotinic, GABA receptors are example of
A. Enzyme linked receptors C.
Intracellular receptors
B. G protein receptors D.
ligand gated receptors
Q8.Match the following
1. Chloramphenicol a. Blue baby syndrome
2. Nimesulide b. liver toxicity
3. Aspirin c. grey baby syndrome
d. Reye’s syndrome
A. 1-a,2-b,3-c C.
1-c,2-d,3-a
B.1-c.2b,3-d D.
1-a, 2-b,3-c
Q.9 Olfactory receptors, chemokine receptors, inflammation mediators, Opsin
protein are
A. enzyme linked receptors C.
Intracellular receptors
B. G protein receptors D.
ligand gated receptors
Q. 10. Tetracycline is not taken with
A. sugar water C.
alluminium hydroxide antacid
B. milk D.
both b and c
Q11. Intraosseous route of administration is
A. bone C.plasma
B. CSF D.none
of these
Q12. Epinephrine is given with lidocaine(anesthetic) because-
A. acts as vasoconstrictor acting
leading to local effect C. for
better stability
B. for general effect D.for
slow drug release
Q13. Hyluronidase
A. increases the absorption rate
of parenteral fluids given subcutaneously
B. is used in antiaging creams
C. ophthalmic surgery, in
combination with local anesthetics
D. both a and c
Q14. People with liver diseases will show
A.Quick
drug action and low distribution of drug
B.Slow
drug action and high distribution of drug
C.Quick
action and high distribution of drug
D.Slow
drug and low distribution of drug
Q15. Administration of drug along with food
leads to
A.Slow
action of drug
B.Quick
action of drugs
C.Slow
or quick action depending on drug interaction
D.Makes
no difference
Q16. Which of the following route doesnot involve use of needle
A.Intravenous
B.Intrathecal
C.Sialistic
implants
D.Dermojets
Q17. Nicotine patches is taken transdermally
A.For
smoking cession
B.Looks
cool
C.For
people who don’t like to smoke
D.None
of these
Q18. Aspirin and naproxen are
absorbed from the stomatch because
A.Because
they are weakly basic drugs and they
dissociate to greater extent
B.Because
they are weakly acidic drugs and they dissociate to greater extent
C.Because
they are weakly acidic drugs and they don’t
dissociate to greater extent
D.Both
a and b
Q19. To overcome phenobarbital(weak acid) overdose the urine should be made
A.Strongly Acidic
B.Strongly
Basic
C.Weakly basic
D.Weakly acidic
Q20. Drug at high
concerteration shows
A.First order kinetics
B.Second order kinetics
C.Zero order kinetics
D.Third order kinetics
Monday 5 March 2012
Carbohydarate metabolism test -1
Q 1. 2, 3-Bisphosphoglycerate
binds with greater affinity to -
A.Deoxygenated
hemoglobin C. both with similar affinity
B. Oxygenated hemoglobin D. none of the above
answer- A
2, 3-Bisphosphoglycerate
binds with greater affinity to Deoxygenated
hemoglobin. it is formed through rapoport luebering pathway.
Q 2. Hexokinase ….
A. has lesser substrate affinity
than glucokinase C. Present in liver
B. Can phosphorylate
fructose D. both a and b
answer-B
hexokinase is present in almost all cells of body which can phosphorylate hexose sugars. It has greater substrate affinity than glucokinase. glucokinase is present in liver
Q3. Glucokinase and hexokinase are isozymes. They
have similar function. Are they coded by the same gene?
A.Yes
C. coded by different alleles of the same gene
B.No
D. none of the above
Q3. Why is
Hmp shunt (PPP pathway) dominant in cornea and erythrocytes?
A. no particular reason C. Increased rate of glycolysis
B. because of being directly
exposed to D. in cornea
because it’s avascular and in RBC because
Oxygen thus generating free radicals of lack of
mitochondria
Q4. Hmp pathway
occurs in
A.Mitochondrion
C.
nucleus
B. Cytosol D. All of these
Q5. What is added to blood for accurate measurement of blood glucose
level?
A. sodium C.
magnesium
B . Fluoride
D. potassium
Q6. People with
defect in glucose 6- phosphate dehydrogenase deficiency (HMP pathway) are
immune to?