Carbohydarate metabolism test -1



Q 1.  2, 3-Bisphosphoglycerate binds with greater affinity to -

A.      Deoxygenated hemoglobin                      C.  both with similar affinity

        B.  Oxygenated hemoglobin                          D. none of the above

answer-  A
 2, 3-Bisphosphoglycerate binds with greater affinity to Deoxygenated hemoglobin. it is formed through rapoport luebering pathway.

Q 2.  Hexokinase ….

A. has lesser substrate affinity than glucokinase                C.   Present in liver

B. Can phosphorylate fructose                                    D. both a and b

answer-B
hexokinase is present in almost all cells of body which can phosphorylate hexose sugars. It has greater substrate affinity than glucokinase. glucokinase is present in liver
 

Q3.  Glucokinase and hexokinase are isozymes. They have similar function. Are they coded by the same gene?

A.      Yes                                                                      C.  coded by different alleles  of the same gene

B.      No                                                                  D. none of the above

Q3.  Why is Hmp shunt (PPP pathway) dominant in cornea and erythrocytes?

A.    no particular reason                                            C.  Increased rate of glycolysis

B. because of being directly exposed to                D. in cornea because it’s avascular and in RBC because  

 Oxygen thus generating free radicals                          of lack of mitochondria

Q4. Hmp pathway occurs in

A.      Mitochondrion                                               C. nucleus

B.     Cytosol                                                                D. All of these

Q5. What is added to blood for accurate measurement of blood glucose level?

A. sodium                                                                         C. magnesium

B . Fluoride                                                                 D. potassium

Q6. People with defect in glucose 6- phosphate dehydrogenase deficiency (HMP pathway) are immune to?

A.      typhoid                                                             C. Malaria

B. Diabetes                                                                  D. TB

Q7. Glucose 6- phosphate dehydrogenase affects mostly?

A.      Males                                                                 C.  Never affects males

B. Females                                                                                  D. Never affects females

Q8.  The ratio of NAD/NADH is higher in

A.      Cytosol                                                              C.  same everywhere

B. Mitochondria                                                         D. differs with cell types

Q9. How many ATP would be gained if all dihydroxy acetone phosphate is used for fatty acid synthesis glycolysis?

A.      0 ATP                                                                  C.  2 ATP

B.      4   ATP                                                                               D. 6 ATP

Q 10.Which pathway is important in synthesis of genetic material?

 A. glycolysis                                                                    C. Krebs cycle

B. gluconeogenesis                                                   D. HMP pathway

                                                                                            

Q11. Why large doses of alcohol lead to hypoglycemia?

A.     decreased NAD+ concentration                    C.  Increased conversion of pyruvate to lactate

B. increased NAD+ concentration                          D.  both a and b

Q12. Why gluconeogenesis does not take place in the brain, adipose tissue and muscles?

A.      They need continuous supply of glucose and hence can’t wait for gluconeogenesis

B.      Gluconeogenesis requires a lot of energy for glucose manufacture

C.      They don’t have enzyme glucose 6- phosphatase

D.       Still a matter of ongoing research

Q13. Increased lactate dehydrogenase indicates?

A.      Myocardial  infarction

B.      Cancer (lymphoma)

C.      Liver disease

D.      All of the above

Q14. The action of amylase (salivary and pancreatic) is

A.      Same to that of  glycogen phosphorylase

B.      Acts on α-1,4-glycosidic bonds

C.      Its involved in gluconeogenesis

D.      Its acts on α-1,6-glycosidic bonds

Q15. Glycogenin is

A.      Only an enzyme

B.      Acts as the primer, to which further glucose monomers may be added.

C.      Enzyme is UTP glucose phosphorylase

D.      Both b and c

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